Gritstone Announces Positive Clinical Results From First Cohort Of A Phase 1 Study (CORAL-BOOST) Evaluating A T Cell-Enhanced Self-Amplifying MRNA (samRNA) Vaccine Against COVID-19

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The Street

By GlobeNewswire — Single 10 µg dose of samRNA vaccine containing Spike plus additional T cell epitopes (TCE) induced robust neutralizing antibody titers in ten healthy adults ≥ 60yrs who had received two prior doses of AstraZeneca’s COVID-19 vaccine — — samRNA vaccine elicited broad CD8+ T cell responses against conserved non-Spike SARS-CoV-2 epitopes and boosted pre-existing Spike-specific T cells — — samRNA vaccine was well-tolerated in these subjects, with no grade 3 or 4 adverse events observed — — Gritstone is expanding CORAL-BOOST to 120 subjects, potentially enabling more ra…

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